Fibronectins: multifunctional modular glycoproteins.
نویسندگان
چکیده
منابع مشابه
Fibronectins: multifunctional modular glycoproteins
Fibronectins are large glycoproteins that have been implicated in a wide variety of cellular properties, particularly those involving the interactions of cells with extracellular materials. These properties include cell adhesion, morphology, cytoskeletal organization, migration, differentiation, oncogenic transformation, phagocytosis, and hemostasis. During the past several years, investigation...
متن کاملMultifunctional materials through modular protein engineering.
The diversity of potential applications for protein-engineered materials has undergone profound recent expansion through a rapid increase in the library of domains that have been utilized in these materials. Historically, protein-engineered biomaterials have been generated from a handful of peptides that were selected and exploited for their naturally evolved functionalities. In recent years, t...
متن کاملModular assembly of thick multifunctional cardiac patches.
In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisot...
متن کاملCarbohydrate Heterogeneity of Fibronectins
Large quantities of fibronectin (Fn) are present in inflammatory synovial fluid. Inflammatory synovial fluid Fn, while indistinguishable from plasma Fn on the basis of reactivity to polyclonal antibodies, displays alterations in molecular size and charge. Since biochemical differences between plasma and synovial fluid fibronectins might be in part due to differences in glycosylation we have com...
متن کاملRole of Glycosylati̇on
Fibronectins are the group of large, multifunctional adhesive glycoproteins that play a significant role in promoting cell adhesion, cell shape and spreading, wound healing and particularly in extracellular matrix (ECM) formation. There are at least two major classes of fibronectins which are termed ‘‘cellular fibronectin’’ and ‘‘plasma fibronectin’’. Cellular fibronectin is produced mainly by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1982
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.95.2.369